Automated Cryogenic Bead Formation System for Micro Droplet Dispensing into Liquid Nitrogen
This system is a precision cryogenic droplet dispensing platform integrating a Micrava ceramic pump with an XYZ gantry motion control system.
The platform is designed with multiple-position sample stations (4 / 8 / 12 positions), allowing users to place insulated containers filled with liquid nitrogen (supplied by the customer).

The system precisely dispenses liquid droplets (typically ≥5 μL) into liquid nitrogen, where droplets are instantly frozen into uniform spherical beads.
Due to the high accuracy and consistency of the dispensing process, the formed beads are smooth, uniform, and structurally stable, making them suitable for downstream freeze-drying processes for long-term storage.
This technology provides an effective solution for improving the stability, transportability, and storage of sensitive biological and diagnostic reagents.


Industry Challenges
1. It's hard to get consistent micro-droplet size when droplets just fall freely
2. Droplet formation becomes unstable because surface tension keeps changing
3. Frozen beads in liquid nitrogen often end up not being round and uniform
4. Manual dripping methods make it tough to get the same results repeatedly
5. There's no precise control over when and where each droplet is released
6. Beads can stick together or get deformed during freezing
System Core Components
Modular Cryogenic Bead Formation Modules
1. Ceramic Precision Metering Pump
High-accuracy micro liquid dosing for stable droplet generation.
2.Motion-Controlled Dispensing System
Enables precise spatial control of droplet formation.
3. Cryogenic Freezing Container (LN2 System)
Provides instant freezing environment for droplet solidification.
4. Dispensing Needle Assembly
High-precision nozzle for controlled droplet release.
Related Solutions
1. Reagent Dispensing Platform
2. Cryogenic Dispensing Solution
5. Automation Fluid Control Platform
Need a Customized Bead Production System?
Micrava provides tailored cryogenic bead formation systems based on:
1. Droplet size requirements
2. Bead uniformity specifications
3. Biological activity preservation needs
4. Production throughput requirements
5. Automation integration level
Engineering Support
System design consultation
2. Process optimization support
3. OEM / ODM customization
Automation integration
Application feasibility testing


